- Our expertise, including our extensive experience
with highly refined animal models for cancer and infectious
diseases, allows us to evaluate proteins extremely efficiently.
- Whether we produce a protein for a client or the client
brings a protein to us which they have created, we have
exceptional expertise to analyze its physical and functional
properties. This analysis can include:
· Product properties
· Correct molecular weight
· Assembly
· Glycosylation
· Antigen biding
· Antibody effector functions including Complement
activation, Fc receptor binding, and antibody dependent
cellular cytotoxicity
· Non-antibody effector functions of protein fusions
including receptor binding, proliferation, cytotoxic activity,
apoptosis and chemotactic activity
- For any protein, including antibodies and antibody protein
fusions we can provide highly reliable pre-clinical studies
including:
· Half-life
· Biodistribution
· In vivo stability
· Toxicity
· Efficacy including tumor targeting, anti-tumor
activity and anti-infectuous activity
|